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Computational design and experimental construction of stable enzymes

Computational design and experimental construction of stable enzymes

Proteins represent an essential component of all living organisms, where they play numerous roles. Nowadays, there is a deep interest in the improvement of various protein characteristics due to their wide use. However, those proteins are exposed to harsh environmental conditions that can lead to their aggregation, denaturation or the loss of their biological function. The main goal of this work was to design and measure variants of the protein DhaA,  more specifically new variants based on the enzyme DhaA115, that was designed by Loschmidt Laboratories with the use of the bioinformatics tool FireProt. Improved variants of this protein are used in biotechnology, mostly for the elimination of toxic compounds from the environment.
This research was focused on the  comparison of six variants.

Lucia Cengelova

20 years

Stand16
ProjectChemistry-04
CountrySlovakia

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