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The use of encapsulation of cross-linked polysaccharide salts and micelles as a carrier for hydrophobic medicinal substances

The use of encapsulation of cross-linked polysaccharide salts and micelles as a carrier for hydrophobic medicinal substances

Micelles were created with incorporated hydrophobic dye (a hydrophobic drug analog). Then, microparticles were made from sodium alginate in which the previously prepared micelles were encapsulated. 2 cross-linking solutions were used (calcium chloride, iron nitrate) and microparticles were observed under a laser confocal microscope (LCM) to confirm the presence of the dye inside the microparticles. After 24hrs, the microparticles were soaked for 45 min. in solutions imitating gastric and intestinal juices and then were analyzed using LCM. The microparticles cross-linked in calcium chloride were broken down in the intestinal and not in the gastric juice. However, the microparticles enclosed in the iron nitrate released the dye in both solutions simulating gastric and intestinal juices.

Róża Wilkońska

19 years

Stand69
ProjectMedicine-06
CountryPoland

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